VeriQuant
Human IL-1β VeriQuant Immunoassay Kit
รหัสสินค้า: VQ1074H
ผู้ผลิต: Reed Biotech
ขนาด:
96 T
ราคา: กรุณาสอบถาม
- สปีชีส์
- Human
- ความไว
- 0.077pg/mL
- ช่วงการตรวจวัด
- 0.32-5000 pg/mL
Product Details
| Product Name | Human IL-1β VeriQuant Immunoassay Kit | Species | Human |
| Gene Alias | IL-1, IL1-BETA, IL1B, IL1beta, IL1F2 | Gene ID | 3553 |
| Uniprot ID | P01584 | Protein Alias | IL1B, IL1-BETA, IL1F2, catabolin, IL1b, IL-1B, IL-1b,Catabolin, IL-1 beta, Hematopoietin 1 (H1), IFN beta inducing factor, il 1b, IL 1β, IL1 B, IL1β, Osteoclast activating factor (OAF), Pro interleukin 1 beta, ILN, Interleukin, Interleukin 1 beta precursor, Interleukin1 beta, Interleukin-1b, LAF, IL1B, interleukin 1 precursor polypeptide, interleukin 1beta, Interleukin-1 beta, preinterleukin 1 beta, pro-interleukin-1-beta, unnamed protein product |
| Detection Method | Proximity-based Immunoassay | Sensitivity | 0.077pg/mL |
| Assay Instrument | qPCR Instruments | Detection Range | 0.32-5000 pg/mL |
| Sample Type | Serum, Plasma, Tissue homogenates, Cell lysates, Cell culture supernates and Other biological fluids；Sample Volume=1~5μL | ||
| Total Assay Time | 2 H | Manual Handling Time | 20 min |
| Shipping Temperature | Ultra-low temperature phase-change materials | Storage Temperature | -20°C |
| No Washing Step | Yes | Tag or Dye | FAM™ |
| Kit Info | The Human IL-1β VeriQuant Immunoassay Kit is designed for the high-sensitivity quantitative measurement of Human IL-1β protein in minimal sample volumes. Utilizing our proprietary ReedLytix conjugation system coupled with Proximity Ligation Assay (PLA) technology, this kit integrates the specific antigen recognition of high-affinity antibodies with the exponential signal amplification power of qPCR. The result is a robust next-generation protein quantification platform. With a simple workflow, results can be obtained from sample to answer in just 2 hours. Data exported from your qPCR instrument can be directly analyzed via our online calculation tool at: https://www.reedbiotech.com/list/114.html ①Ultra-Sensitivity: All products achieve femtogram-level sensitivity ②Wide Range: Product detection range spans 6-log dynamic range ③Micro-Volume: Minimum sample size is only 1μL ④Fast: Results in 2 Hours(30 minutes of manual handling),no plate washing ⑤ALL IN ONE: Can replace traditional, high-sensitivity, micro-fast, fast-step, wide-range ELISA kits simultaneously |
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| Target Info | Interleukin-1 beta (IL-1 beta) is a proinflammatory cytokine expressed by monocytes, macrophages, and dendritic cells. IL-1 beta is synthesized in response to inflammatory stimuli as a 31 kDa inactive pro-form that accumulates in the cytosol. Cleavage of pro-IL-1 beta into the active 17 kDa protein requires the activation of inflammasomes, which are multi-protein complexes that respond to pathogens, stress conditions, and other danger signals. Inflammasome activation triggers the processing of the caspase-1 precursor into its active form, which in turn cleaves pro-IL-1 beta. IL-1 beta lacks a signal sequence peptide for classical ER/Golgi pathway and is secreted alongside caspase-1 via an alternate and incompletely understood mechanism. Although IL-1 beta is most often secreted in its active form, secretion of the uncleaved protein may be detectable under some biological conditions. IL-1 beta signals through two receptors, IL-1RI and IL-1RII, both of which are shared with IL-1 alpha. IL-1 beta activity can be moderated by IL-1 Receptor Antagonist (IL-1RA), a protein produced by many cell types that blocks receptor binding through competitive inhibition. IL-1 beta play an important role in innate host defense by triggering the production of other proinflammatory cytokines in target cells and initiating acute-phase responses to infection and injury. Elevated levels of IL-1 beta have been associated with many chronic inflammatory conditions IL-1 beta neutralizing antibodies potential therapeutic value. | ||
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